منابع مشابه
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity
IL-5 expresses various biologic effects on several types of lymphocytes, including B cells, eosinophils, and T cells. We demonstrated that the incubation of resting splenocytes from C57BL/6 mice in murine rIL-5 enhances IL-2-mediated lymphokine-activated killer (LAK) activity against various tumor cells. IL-5 alone, however, does not induce killer activity. IL-2-mediated LAK activity increases ...
متن کاملCorrelation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple sclerosis.
Concentrations of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) in serum and CSF samples were measured in 63 patients with multiple sclerosis (MS) to evaluate their usefulness as markers of disease activity. CSF concentrations of IL-2 and sIL-2R were significantly higher in MS relapse compared with MS patients in remission or with control subjects. These concentrations correlated with...
متن کاملMyelostimulatory activity of recombinant human interleukin-2 in mice.
In a series of studies designed to extend our understanding of interleukin-2 (IL-2) and to study the effect of biologic response modifiers on bone marrow, we observed that administering recombinant human (rH) IL-2 to normal mice resulted in an increase in the frequency of colony-forming units-culture (CFU-C) in bone marrow. In addition, rH IL-2 was able to accelerate host recovery from cyclopho...
متن کاملIn vivo activity of solid phase interleukin 2.
Interleukin 2 (IL-2) coupled to polystyrene beads to form a solid phase of the cytokine was able to increase the cytotoxic activity of rat spleen cells in vitro. A single injection of the IL-2 coupled beads into the peritoneal cavities of normal rats also resulted in the in vivo activation of cytotoxicity of peritoneal exudate cells, whereas a single i.p. injection of the same amount of soluble...
متن کاملStudies of structure-activity relationships of human interleukin-2.
Human interleukin-2 (IL-2) has 3 cysteine residues; cysteines 58 and 105 form an intramolecular disulfide bridge, whereas cysteine 125 has a free sulfhydryl group. In this study, site-specific mutagenesis has been used to modify the cysteine residues of recombinant Escherichia coli-derived IL-2 (rIL-2) to evaluate the functional structure of IL-2. Substitution or deletion of cysteine 105 disrup...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Japanese Journal of Veterinary Science
سال: 1986
ISSN: 0021-5295,1881-1442
DOI: 10.1292/jvms1939.48.529